FUNCTIONAL FIBRINOGEN ASSAY INDICATES THAT FIBRINOGEN IS CRITICAL IN CORRECTING ABNORMAL CLOT STRENGTH FOLLOWING TRAUMA
نویسندگان
چکیده
منابع مشابه
Functional evaluation of an inherited abnormal fibrinogen: fibrinogen "Baltimore".
The rate of clotting and the rate of development and degree of turbidity after addition of thrombin to plasma or purified fibrinogen from a patient with fibrinogen Baltimore was delayed when compared with normal, especially in the presence of low concentrations of thrombin. Optimal coagulation and development of translucent, rather than opaque, clots occurred at a lower pH with the abnormal fib...
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Background Fibrinogen supplementation in trauma has been suggested in order to restore or improve haemostatic competence; this could possibly reduce or replace the need for transfusions in case of bleeding. Results from functional haemostatic assays indicate that lowered clot strength is associated with a risk for massive transfusions [1]. The optimal fibrinogen concentration or indications for...
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متن کاملFibrinogen ""New York"--an abnormal fibrinogen associated with thromboembolism: functional evaluation.
A 54-yr-old woman presented with a 23-yr history of repeated life-threatening thromboembolism. The presence of a qualitatively abnormal fibrinogen was suggested by the demonstration of delayed and incomplete coagulation of plasma or partially purified fibrinogen by thrombin or Reptilase. Two brothers showed a similar in vitro defect but were clinically not affected. The plasma fibrinogen concen...
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ژورنال
عنوان ژورنال: Shock
سال: 2013
ISSN: 1073-2322
DOI: 10.1097/shk.0b013e3182787122